Title:
Nb▲3▼Sn化合物超電導線の製造方法
Document Type and Number:
Japanese Patent JP3602151
Kind Code:
B2
Abstract:
Benzoylacrylamide derivatives of the formula (I): ![]()
(I) wherein R1 and R2 each independently represent a hydrogen atom, C1 ~ C5 alkyl, C3 ~ C8 cycloalkyl optionally intervened by -NR8- (R8 represents phenyl or C1 ~ C5 alkyl which is unsubstituted or substituted with phenyl), ![]()
(n is an integer of 0 to 3 and X and Y each independently represent a hydrogen atom, a halogen atom, C1 ~ C5 alkyl or C1 ~ C5 alkoxy), -(CH2)m-A (m is an integer of 0 to 3 and A represents an optionally substitued heterocycle), -COR9 (R9 represents C1 ~ C5 alkyl which is unsubstituted or substituted with phenyl, phenyl which is unsubstituted or substituted with C1 ~ C5 alkyl or a halogen atom, or C1 ~ C5 alkoxy which is unsubstituted or substituted with phenyl) -SO2R10 (R10 represents C1 ~ C5 alkyl which is unsubstituted or substituted with phenyl or a halogen atom, or phenyl which is unsubstituted or substituted with C1 ~ C5 alkyl), or -OR11 (R11 represents a hydrogen atom, or C1 ~ C5 alkyl which is unsubstituted or substituted with phenyl); or when R1 and R2 are taken together, they represent C3 ~ C6 alkylene optionally intervened by -O- or -NR12- (R12 represents a hydrogen atom, phenyl or C1 ~ C5 alkyl); and R3, R4, R5, R5 and R7 each independently represent a hydrogen atom, a halogen atom, C1 ~ C5 alkyl which is unsubstituted or substituted with a halogen atom or -OR13 (R13 represents a hydrogen atom or C1 ~ C5 alkyl which is unsubstituted or substituted with a halogen atom or phenyl); or when their adjacent substituents are taken together, they represent C1 ~ C3 oxyalkylene having one or two oxygen atoms, and pharmaceutically acceptable salts thereof, and a pharmaceutical composition containing at least one of these compounds, which is useful as a tyrosine kinase inhibitor and useful for suppressing the growth of cnacer cells.
Inventors:
Osamu Taguchi
Kiyoshi Hiramoto
Kiyoshi Hiramoto
Application Number:
JP1289393A
Publication Date:
December 15, 2004
Filing Date:
January 28, 1993
Export Citation:
Assignee:
Mitsubishi Electric Corporation
International Classes:
B21F19/00; A61K31/165; A61K31/33; C07C235/78; C07C235/88; C07D207/337; C07D209/20; C07D211/58; C07D213/75; C07D295/185; C07D307/54; C07D317/60; C07D333/24; C22F1/00; H01B12/10; H01B13/00; (IPC1-7): H01B13/00
Domestic Patent References:
| JP56126205A | ||||
| JP5012934A |
Attorney, Agent or Firm:
Michiteru Soga
Yoshio Kobayashi
Yutaka Ikeya
Hidetoshi Furukawa
Suzuki Kenchi
Masahisa Hase
Tetsuo Kuroiwa
Yoshio Kobayashi
Yutaka Ikeya
Hidetoshi Furukawa
Suzuki Kenchi
Masahisa Hase
Tetsuo Kuroiwa