Title:
臨床検査用複合酵素含有組成物
Document Type and Number:
Japanese Patent JP3625503
Kind Code:
B2
Abstract:
Disclosed is a stabilized enzyme composition for use in clinical examination, comprising: (a) an enzyme component comprising at least two enzymes selected from the group consisting of alkaline phosphatase, creatine kinase and alanine aminotransferase; (b) a stabilizer component comprising effective stabilizing amounts of an albumin, and at least one saccharide selected from the group consisting of trehalose and sorbitol; and (c) an aqueous medium having dissolved therein the components (a) and (b). The enzyme composition of the present invention is stable for a prolonged period of time not only under non-freeze refrigeration conditions, but also under freezing conditions or under conditions for non-freeze refrigeration after thawing of the frozen composition, as compared to the conventional enzymatic compositions. The enzyme composition of the present invention can be advantageously used for the purpose of checking the precision in measurement, correcting measured values and calibrating the amount and activity of an enzyme, in a clinical examination for measuring the enzymatic activity in a sample, such as serum or the like.
Inventors:
Ryoji Aoki
Ueda Shigeru
Ueda Shigeru
Application Number:
JP27761794A
Publication Date:
March 02, 2005
Filing Date:
November 11, 1994
Export Citation:
Assignee:
Asahi Kasei Pharma Co., Ltd.
International Classes:
C12Q1/32; C12Q1/42; C12Q1/48; C12Q1/50; C12Q1/52; G01N33/50; G01N33/96; (IPC1-7): C12Q1/42; C12Q1/32; C12Q1/48; C12Q1/50; C12Q1/52; G01N33/50