Title:
細胞増殖抑制剤の発酵生産方法及びそれらの結晶体
Document Type and Number:
Japanese Patent JP3681109
Kind Code:
B2
Abstract:
The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
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Inventors:
Hans Hoffman
Marion Manke
Klaus Memmert
Frank Petersen
Thomas Sup
Ernst Custers
Michael Muts
Marion Manke
Klaus Memmert
Frank Petersen
Thomas Sup
Ernst Custers
Michael Muts
Application Number:
JP2000532542A
Publication Date:
August 10, 2005
Filing Date:
February 17, 1999
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K31/427; A61P35/00; A61P35/04; A61P43/00; B01D15/08; C07D493/04; C12N1/14; C12P17/16; C12P17/18; C12R1/01; C12R1/645; A61K31/00; B01D15/00; C12P; (IPC1-7): C12P17/18; C12N1/14
Domestic Patent References:
| JP8140690A | ||||
| JP8510232A |
Foreign References:
| WO1993010121A1 | ||||
| WO1999039694A2 | ||||
| DE4207922A |
Other References:
Journal of Antibiotics,1996,49(6),p.560-563
鈴木節士,シクロデキストリンの発酵生産への応用,バイオサイエンスとバイオインダストリー, 1989, 47(1), p.42-44
Appl.Microbiol.Biotechnol.,1987,26,p.522-526
Nature,1997,387(6630),p.268-272
鈴木節士,シクロデキストリンの発酵生産への応用,バイオサイエンスとバイオインダストリー, 1989, 47(1), p.42-44
Appl.Microbiol.Biotechnol.,1987,26,p.522-526
Nature,1997,387(6630),p.268-272
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
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