Title:
プロテアーゼ阻害剤および抗ウイルス剤としての5,6-ジヒドロピロン誘導体
Document Type and Number:
Japanese Patent JP3684426
Kind Code:
B2
Abstract:
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.
Inventors:
Edmund Lee, Ellsworth
Lenny, Elizabeth
Tate, Bradley Dane
Lenny, Elizabeth
Tate, Bradley Dane
Application Number:
JP51445895A
Publication Date:
August 17, 2005
Filing Date:
October 26, 1994
Export Citation:
Assignee:
Park Davis and Company
International Classes:
A61K31/35; A61K31/351; A61K31/352; A61K31/365; C07D335/02; A61K31/366; A61K31/44; A61K31/443; A61K31/4433; A61K31/48; A61P31/04; A61P31/12; A61P31/18; C07C323/22; C07C381/04; C07D211/84; C07D211/86; C07D309/32; C07D309/38; C07D311/96; C07D405/04; C07D405/12; C07D407/06; C07D409/04; (IPC1-7): C07D309/32; A61K31/366; A61P31/18
Domestic Patent References:
| JP8503216A | ||||
| JP49075583A |
Foreign References:
| WO1988004652A1 |
Other References:
J.D.White et al, Darzens condensation of α-halolactones. Glycidic lactones as intermediates in acetogenin synthesis, Journal of the American Chemical Society, 米国,American Chemical Society, Washington, 1971年,93巻1号,p.281-282
Ali M. Chirazi et al, Syntheses of heterocycles, 184. The synthesis of kawalactone derivatives, Archiv der Pharmazie, ドイツ,Wiley-VCH, Weinheim, 1976年,309巻7号,p.558-564
Gioachino Falsone et al, Synthesis of disubstituted 3-methylene-2-oxotetrahydrofurans and their rearrangement to・・・,Archiv der Pharmazie, ドイツ,wiley-VCH, Weinheim, 1982年,315巻6号,p.491-498
Ali M. Chirazi et al, Syntheses of heterocycles, 184. The synthesis of kawalactone derivatives, Archiv der Pharmazie, ドイツ,Wiley-VCH, Weinheim, 1976年,309巻7号,p.558-564
Gioachino Falsone et al, Synthesis of disubstituted 3-methylene-2-oxotetrahydrofurans and their rearrangement to・・・,Archiv der Pharmazie, ドイツ,wiley-VCH, Weinheim, 1982年,315巻6号,p.491-498
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura