Title:
コラーゲン刺激血小板凝集の阻害剤
Document Type and Number:
Japanese Patent JP3742429
Kind Code:
B2
Abstract:
PCT No. PCT/EP94/02087 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01375 PCT Pub. Date Jan. 12, 1995A protein isolated from crude extracts of Hirudo medicinalis is disclosed, which strongly inhibits the binding to collagen of platelets and their subsequent activation, which leads to platelet aggregation and thrombus formation. Additionally the protein prevents binding of von Willebrand factor to collagen. Described is a method for isolation and purification of the protein as well as its use for blocking collagen-stimulated platelet aggregation. The new protein (Brandinin) has a molweight of approximately 15 kD, binds to collagen but has no collagen-cleaving activity. The protein is useful in the prophylaxis, prevention and treatment of thrombotic diseaeses and for coating of blood-contacting materials, rendering them thromboresistant.
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Inventors:
Hemberger, Jürgen
Melzer, Guido
Melzer, Guido
Application Number:
JP50326095A
Publication Date:
February 01, 2006
Filing Date:
June 28, 1994
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K38/00; C07K14/435; A61K35/62; A61K38/17; A61P7/02; C07K1/16; C07K1/18; A61K39/00
Domestic Patent References:
| JP5086098A |
Other References:
The Journal of Biological Chemistry, Vol.267(10), p.6893-6898 (1992)
Prostaglandins, Vol.43(5), p.483-495 (1992)
Prostaglandins, Vol.43(5), p.483-495 (1992)
Attorney, Agent or Firm:
Akio Miyazaki
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki