Title:
PDE▲IV▼およびTNF抑制剤としての化合物
Document Type and Number:
Japanese Patent JP3775685
Kind Code:
B2
Abstract:
This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. The present invention is therefore directed to their pharmacological use for inhibiting TNF and/or cyclic AMP phosphodiesterase, pharmacological compositions comprising the compounds and methods for their preparation.
Inventors:
Fenton, Geary
Majid, Tahil Nadeem
Parfleyman, Malcolm Norman
Majid, Tahil Nadeem
Parfleyman, Malcolm Norman
Application Number:
JP50565795A
Publication Date:
May 17, 2006
Filing Date:
July 28, 1994
Export Citation:
Assignee:
Loan-Poulin Lore Limited
International Classes:
C07C43/225; A61K31/09; C07D239/42; A61K31/137; A61K31/165; A61K31/167; A61K31/196; A61K31/42; A61K31/425; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/4418; A61K31/4439; A61K31/444; A61K31/455; A61K31/495; A61K31/4965; A61K31/50; A61K31/501; A61K31/505; A61K31/53; A61P1/04; A61P3/10; A61P7/12; A61P11/00; A61P11/06; A61P11/08; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P19/08; A61P25/00; A61P25/28; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07C43/247; C07C217/58; C07C235/56; C07C237/30; C07C255/60; C07C317/14; C07C323/20; C07C323/65; C07C325/02; C07C327/42; C07C327/48; C07D213/50; C07D213/61; C07D213/65; C07D213/66; C07D213/69; C07D213/70; C07D213/75; C07D213/80; C07D213/81; C07D213/82; C07D213/89; C07D237/14; C07D239/46; C07D241/18; C07D241/20; C07D253/06; C07D261/14; C07D275/02; C07D401/12; C07D413/12
Other References:
CARVALHO,C.F. et al., Phenanthrene Synthesis: The Synthesis of Juncunone and the Micandrols-A, B, E, and F, J.CHEM.SOC.PERKIN TRANS. I, 1984年,No.8, p.1913-1918
Attorney, Agent or Firm:
Heikichi Odashima