Title:
アポリポタンパク質-B合成阻害剤としての新規なトリアゾロン
Document Type and Number:
Japanese Patent JP3782455
Kind Code:
B2
Abstract:
The present invention concerns novel compounds of formula (I).wherein R1 is C1-10alkyl, C3-7cycloalkyl or C1-6alkyl substituted with C3-7cycloalkyl; R2 is hydrogen or C1-6alkyl; Alk represents C1-3alkanediyl; -A- represents a bivalent radical of formula -CH=CH-N=CH- (a), -N=CH-N=CH- (b), -CH=N-N=CH- (c), -CH=CH-CH=N- (d); in said bivalent radicals a hydrogen atom may be replaced by C1-6alkyl; and Ar is unsubstituted phenyl; phenyl substituted with up to two substituents selected from halo, C1-6alkyl or C1-6alkyloxy; unsubstituted naphthyl; or naphthyl substituted with up to two substituents selected from halo, C1-6alkyl or C1-6alkyloxy; the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof. The present invention further comprises the pharmaceutical compositions comprising compounds of formula (I), the preparation thereof as well as the use as a medicine in the treatment of hyperlipidemia.
Inventors:
Jerez, Jiang
Batuks, Leo Jakobs Ziosef
Liuitz, Paul August Clement
De Schaoi de Coursel, Deideier Robert Guy Gabriel
Batuks, Leo Jakobs Ziosef
Liuitz, Paul August Clement
De Schaoi de Coursel, Deideier Robert Guy Gabriel
Application Number:
JP53146096A
Publication Date:
June 07, 2006
Filing Date:
April 12, 1996
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D405/14; A61K31/495; A61P3/06; C07D405/06; C07D521/00
Domestic Patent References:
| JP62158275A | ||||
| JP59172486A | ||||
| JP63277674A |
Other References:
H. Vanden Bossche, Interaction of Azole Dericatives with Cytochrome P-450 Isozymes in Yeast, Fungi, Plants and Mammalia, Pestic. Sci., 1987年,Vol.21, Pages 289-306
SUEZAWA Hiroko, 13C-NMR Spectra of 2-Aryl-2-(1-azolylmethyl)-4-hydroxymethy1-1,3-dioxolanes and Their Ester, The Chemical Society of Japan,1984年,Vol.57, Pages 883-884
竹内 烈,cis-1-[2-Phenyl-4-(phenoxy or Phenylthio)methyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole誘導体の合成と,薬学雑誌,1985年,Vol.105, No.6, Pages 554-561
SUEZAWA Hiroko, 13C-NMR Spectra of 2-Aryl-2-(1-azolylmethyl)-4-hydroxymethy1-1,3-dioxolanes and Their Ester, The Chemical Society of Japan,1984年,Vol.57, Pages 883-884
竹内 烈,cis-1-[2-Phenyl-4-(phenoxy or Phenylthio)methyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole誘導体の合成と,薬学雑誌,1985年,Vol.105, No.6, Pages 554-561
Attorney, Agent or Firm:
Heikichi Odashima