フェニルイミダゾリジノン誘導体およびその製造法

Japanese Patent JP3794696

B2

The invention relates to new derivatives of 1-imidazolylalkyl-3-phenyl-imidazolidin-2-ones of general formula (I) (I) wherein n is 1, 2 or 3; each of R, R1 and R2, which may be the same or different, is hydrogen, halogen, hydroxy, cyano, C1-C6 alkyl, CF3, C1-C6 alkoxy, C1-C6 alkylthio, formyl, C2-C6 alkanoyl, carboxy, C1-C6 alkoxy-carbonyl, nitro, -N(R4 R5) in which each of R4 and R5 independently is hydrogen C1-C6 alkyl formyl or C2-C6 alkanoyl; or a (R6 R7)N-SO2 group, in which each of R6 and R7 independently is hydrogen or C1-C6 alkyl; R3 is an imidazolyl group of formula wherein each of R8 and R10 which may be the same or different is hydrogen or C1-C6 alkyl, R9 is hydrogen, C1-C6 alkyl or a nitrogen protecting group, or pharmaceutically acceptable salts thereof, which are useful in the treatment of CNS disorders, such as, e.g., anxiety and psychosis, and in the treatment of gut motility disorders, and/or emesis.

Barashi, Mario
Hayden Pergale, Franco
Carthia, carla
Arrigoni, Claudio

JP51163994A

July 05, 2006

October 22, 1993

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Farmacia e Appzyon Esset Pear

C07D233/61; A61K31/415; C07D403/06; A61K31/4178; A61P1/00; A61P1/08; A61P25/00; A61P25/04; A61P25/06; A61P25/20; A61P25/22; A61P25/26; A61P25/30; A61P43/00; C07D233/32; C07D233/54; C07D233/56

JP4501850A

GB995366A

William B. Wright et al., Central Nervous system Depressants., Journal of Medical Chemistry, 米国,1966年11月,Vol.9,No.6, 852-857
Eric J. Lien et al., Structure-Activity Correlations for teh Central Nervous System Depressant 2-Imidazolidinones, Journal of Medical Chemistry, 米国,1970年 7月,Vol.13,No.4,623-626

Yoshio Kawaguchi
Toru Nakamura
Takeshi Funayama
Naoya Fushimi

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