Title:
リポタンパク質の代謝における欠陥の治療のための遺伝子治療の方法及び組成物
Document Type and Number:
Japanese Patent JP3868489
Kind Code:
B2
Abstract:
The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic cell; and a human VLDL receptor gene operatively linked to regulatory sequences directing its expression. The vector is capable of expressing the normal VLDL receptor gene product in hepatic cells in vivo or in vitro. This viral vector is useful in the treatment of metabolic disorders caused by the accumulation of LDL in plasma, such as familial hypercholesterolemia or familial combined hyperlipidemia.
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Inventors:
Wilson, The Ames M
Karen Kozarski
Strauss, Jerome, The Third
Karen Kozarski
Strauss, Jerome, The Third
Application Number:
JP52587596A
Publication Date:
January 17, 2007
Filing Date:
February 23, 1996
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
C12N15/09; A61K35/76; A61K38/00; A61K38/17; A61K48/00; A61P3/06; C07K14/705; C12N5/10; C12N7/00; C12N15/12; C12N15/861
Foreign References:
| WO1995002697A1 | ||||
| WO1994025073A1 |
Other References:
GAFVELS, M.E. et al., Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor a, Somat. Cell Mol.Genet., 米国,1993年11月,Vol.19, No.6, 557-569
Attorney, Agent or Firm:
Heikichi Odashima