Title:
環状デプシペプチドおよびこれを有効成分とする医薬
Document Type and Number:
Japanese Patent JP3947228
Kind Code:
B2
Abstract:
Cyclic depsipeptides represented by the formula (1) (wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1) or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.
Inventors:
Makoto Taniuchi
Suzuki Masashi
Norio Oshida
Kawamura Koji
Shigeru Hiramoto
Orie Yasuda
Nobusuke Kinoshita
Akiko Makai
Masai Kanai
Suzuki Masashi
Norio Oshida
Kawamura Koji
Shigeru Hiramoto
Orie Yasuda
Nobusuke Kinoshita
Akiko Makai
Masai Kanai
Application Number:
JP50268898A
Publication Date:
July 18, 2007
Filing Date:
June 25, 1997
Export Citation:
Assignee:
Nisshin Flour Milling Group Inc.
International Classes:
C07K7/54; A61K38/00; A61P3/06; A61P25/00; A61P25/28; A61P43/00; C07K7/06
Foreign References:
| WO1995032990A1 |
Other References:
OHNO M, ed. ”Peptide Chemistry 1994”,Protein Research Foundation, 1995, p.33-36
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Kosuke Nishimura