Title:
安定な、水性αインターフェロン溶液処方物
Document Type and Number:
Japanese Patent JP3978228
Kind Code:
B2
Abstract:
Stable aqueous solution formulations containing alfa-type interferon, e.g., interferon alfa-2a and interferon alfa-2b, a buffer to maintain the pH in the range of 4.5-7.1, polysorbate 80 as a stabilizer, edetate disodium as a chelating agent, sodium chloride as a tonicity agent, and m-cresol as an antimicrobial preservative and which maintain high chemical, physical and biological stability of the alfa-type interferon for an extended storage period of at least 24 months are disclosed.
Inventors:
Yuen, Pui-Ho Chi.
Clean, Douglas F.
Clean, Douglas F.
Application Number:
JP51260696A
Publication Date:
September 19, 2007
Filing Date:
October 10, 1995
Export Citation:
Assignee:
Schering Corporation
International Classes:
A61K38/21; A61K9/00; A61K47/42; A61K9/08; A61K47/00; A61K47/02; A61K47/10; A61K47/14; A61K47/18; A61K47/34; A61K47/12; A61K47/26
Domestic Patent References:
| JP63091331A | ||||
| JP60188328A |
Attorney, Agent or Firm:
Hidesaku Yamamoto