Title:
ムスカリンアンタゴニスト
Document Type and Number:
Japanese Patent JP4012068
Kind Code:
B2
Abstract:
Amide derivatives of 1,4 di-substituted piperidine compounds of the formula:or a pharmaceutically acceptable salt, ester or solvate thereof, whereinR1 is optionally substituted cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or heteroaryl;R2 is H, alkyl, or optionally substituted cycloalkyl, cycloalkylalkyl, heterocycloalkyl, bridged cycloalkyl, or bridged heterocycloalkyl;R3 is alkyl or -CH2OH; andR4 is H or alkyl;are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed.
Inventors:
McKitrick, Brian A.
Guo, Guihua
Two, Zaonin
Lee, Yuan Giang
Guo, Guihua
Two, Zaonin
Lee, Yuan Giang
Application Number:
JP2002552905A
Publication Date:
November 21, 2007
Filing Date:
December 17, 2001
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07D211/34; A61K31/445; A61K31/4465; A61K31/451; A61K31/4525; A61K31/453; A61K31/4545; A61K31/46; A61K45/00; A61P25/00; A61P25/28; A61P43/00; C07D401/12; C07D405/04; C07D405/06; C07D451/04
Domestic Patent References:
| JP4312572A | ||||
| JP11501014A | ||||
| JP2000501117A |
Foreign References:
| US6066636 | ||||
| EP0976722A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita