Title:
C型肝炎ウイルスゲノムの新規な3’末端配列並びにその診断及び治療使用
Document Type and Number:
Japanese Patent JP4031511
Kind Code:
B2
Abstract:
The invention relates to the discovery of a novel RNA sequence at the 3' terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3' sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
Inventors:
Charles Rice Third
Alexander A. Koriharov
Alexander A. Koriharov
Application Number:
JP2006333873A
Publication Date:
January 09, 2008
Filing Date:
December 11, 2006
Export Citation:
Assignee:
Washington University
International Classes:
C12N15/09; G01N33/50; A61K31/00; A61K38/21; A61K45/00; A61K48/00; A61P1/00; A61P1/16; A61P31/00; A61P31/12; A61P31/20; A61P35/00; C07K14/18; C12N5/08; C12N5/10; C12N7/00; C12Q1/68; C12Q1/70; G01N33/566; G01N33/576; A61K38/00; A61K39/00
Other References:
Proc. Natl. Acad. Sci. USA,米国,1995年,vol.92,3401-3405
Proc. Natl. Acad. Sci. USA,米国,1991年,vol.88,1711-1715
Proc. Natl. Acad. Sci. USA,米国,1991年,vol.88,10292-10296
Proc. Natl. Acad. Sci. USA,米国,1991年,vol.88,1711-1715
Proc. Natl. Acad. Sci. USA,米国,1991年,vol.88,10292-10296
Attorney, Agent or Firm:
Yoshio Kawaguchi
Katsuma Osaki
Katsuma Osaki