Title:
置換された1-ナフトイルグアニジン、その製法、医薬または診断剤としてのその使用およびそれを含有する医薬
Document Type and Number:
Japanese Patent JP4039587
Kind Code:
B2
Abstract:
1-Naphthoyl-guanidines (I) and their salts are new: R2-R8 = H; F; Cl; Br; I; CN; NO2; CF3; C2F5; or XaYbZ; X = O; S; or NR10, CR11R12, CO, CONR10, COO, SO; SO2, SO2NR10, OCO, NR10CO or NR10SO2 attached to the ring via the left hand atom; R10-R12 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-7C cycloalkyl; Y = 1-8C alkylene with 1 CH2 optionally replaced by O, S, NR13 or o-, m- or p-phenylene; R13 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-6C cycloalkyl; Z = H; 1-7C alkyl; 3-7C cycloalkyl; COR15; SO2R15; NR16R17; or is Ph or a C- or N-linked N-containing 1-9C heterocycle (each optionally mono-, di- or trisubstituted by F, Cl, Br, CF3, Me, OMe or NR21R22); a, b = 0 or 1; R15 = N=C(NH2)2; NR18R19; N(CH2)cNR18R19; or OR20; c = 2 or 3; R16 - R19 = H; 1-8C alkyl; or 1-4C perfluoroalkyl; or R16+R17 or R18+R19 = tetra- or pentamethylene with 1 CH2 optionally replaced by O, S or NQ; Q = H; Me; benzyl; or p-Cl-Ph; R20 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-7C cycloalkyl; R21, R22 = H; 1-4C alkyl; or 1-4C perfluoroalkyl; provided that when R4 = alkoxy, at least one of R2, R3 and R5-R8 is not H.
Inventors:
Joachim Brendel
Heinz-Werner Kleman
Heinrich Kristien Arngrat
Hans Johen Lang
Oud Arbus
Bansi Ral
Anil Vue Santrao Gate
Heinz-Werner Kleman
Heinrich Kristien Arngrat
Hans Johen Lang
Oud Arbus
Bansi Ral
Anil Vue Santrao Gate
Application Number:
JP13822697A
Publication Date:
January 30, 2008
Filing Date:
May 28, 1997
Export Citation:
Assignee:
Hoechst Gesellschaft Mito Beschlenktel Haftung
International Classes:
C07C279/22; A01N1/02; C07D295/14; A01N47/44; A61K31/155; A61K31/165; A61K31/445; A61P3/06; A61P3/10; A61P9/00; A61P9/06; A61P9/10; C07C271/22; C07C279/20; C07C303/40; C07C311/19; C07C315/04; C07C317/50; C07C319/20; C07C323/62
Domestic Patent References:
| JP8041028A | ||||
| JP9067332A | ||||
| JP8059598A | ||||
| JP8225513A |
Foreign References:
| US4251545 |
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura
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