置換インダニリジンアセチルグアニジン類、それらの製造方法、医薬または診断剤としてのそれらの使用およびそれらを含有する医薬 - Hoechst Gesellschaft Mito Beschlenktel Haftung

Title:

置換インダニリジンアセチルグアニジン類、それらの製造方法、医薬または診断剤としてのそれらの使用およびそれらを含有する医薬

Document Type and Number:

Japanese Patent JP4039589

Kind Code:

B2

Abstract:

Indanylidineacetylguanidines I and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and X have the meanings given in the claims, are effective inhibitors of the cellular sodium/proton antiport (Na<+>/H<+> exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes and the like) is also increased in those cells which are readily accessible for measurements, such as, for example, in erythrocytes, platelets or leukocytes.

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Inventors:

Nilogi Venkata Satya Ramah Krisyuna
Arun Kumar Jyain
Bansi Ral
Lao Baeng Kata Sarthea Vera Bhadra Badrum Today
Anil Basantrao Gate
Rabindra Datsutatraya Gupte
Andreas Wueichert
Yan-Robert Schievalk

Application Number:

JP20275697A

Publication Date:

January 30, 2008

Filing Date:

July 29, 1997

Export Citation:

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Assignee:

Hoechst Gesellschaft Mito Beschlenktel Haftung

International Classes:

A61K31/155; A01N1/00; C07C279/22; A61K31/165; A61P3/06; A61P3/10; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P25/00; A61P43/00; C07C327/50; C07C327/54; A61K31/00

Domestic Patent References:

JP8291131A
JP8041028A
JP8027093A

Attorney, Agent or Firm:

Chika Takagi
Tatsuo Sato
Kosuke Nishimura

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