Title:
抗体の産生、及び抗体を含む医療的使用
Document Type and Number:
Japanese Patent JP4053596
Kind Code:
B2
Abstract:
A method of making antibodies to a selected part P of an immunoglobulin molecule ZP, Z comprising the non-selected part of ZP, P being the selected part of ZP which comprises a hidden epitope of the light chain, said method comprises tolerizing the source of antibodies, by administering to the source a compound containing the non-selected part Z or a part of Z and administering antibodies to the non-selected part Z or a part of Z; wherein these administered antibodies are specific to an Fc region of ZP; and immunizing the source of antibodies with part of ZP having the selected part P exposed; and wherein Z comprises non-hidden epitopes of said immunoglobulin molecule, and wherein said compound containing the non-selected part of said molecule comprises a whole immunoglobulin, and wherein immunizing the source of antibodies with part of ZP comprises immunizing with free light chain.
Inventors:
Bradwell, Arthur, Randell
Application Number:
JP51795597A
Publication Date:
February 27, 2008
Filing Date:
October 30, 1996
Export Citation:
Assignee:
The Binding Site Limited
International Classes:
C07K16/18; G01N33/531; A61K39/00; A61K39/08; A61K39/395; C07K16/40; C07K16/42; A61K38/00
Other References:
Analytical Biochemistry, 1986年, Vol.154, pp.373-381
Clinical Chemistry, 1982年, Vol.28, No.11, pp.2254-2258
Biotechniques, 1992年, Vol.12, No.6, pp.842-847
J. Immunol. Methods, 1987年, Vol.100, pp.73-82
Analytical Biochemistry, 1992年, Vol.207, pp.142-149
Clinical Chemistry, 1982年, Vol.28, No.11, pp.2254-2258
Biotechniques, 1992年, Vol.12, No.6, pp.842-847
J. Immunol. Methods, 1987年, Vol.100, pp.73-82
Analytical Biochemistry, 1992年, Vol.207, pp.142-149
Attorney, Agent or Firm:
Satoshi Furuya
Kaoru Furuya
Takahiko Mizobe
Kaoru Furuya
Takahiko Mizobe