Title:
プロスタグランジンD合成酵素の3次元立体構造及びその使用
Document Type and Number:
Japanese Patent JP4071477
Kind Code:
B2
Abstract:
A method of designing an anti-allergic agent, sleep controlling agent, anti-obesity agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.
Inventors:
Takeshi Inoue
Yasushi Kai
Yoshihiro Uraide
Yosuke Okano
Kinugasa Shigehiro
Hiroyuki Matsumura
Daisuke Irikura
Osamu Hayaishi
Yamamoto Masataka
Takashi Kumasaka
Miyano Masashi
Yasushi Kai
Yoshihiro Uraide
Yosuke Okano
Kinugasa Shigehiro
Hiroyuki Matsumura
Daisuke Irikura
Osamu Hayaishi
Yamamoto Masataka
Takashi Kumasaka
Miyano Masashi
Application Number:
JP2001346035A
Publication Date:
April 02, 2008
Filing Date:
November 12, 2001
Export Citation:
Assignee:
Osaka Bioscience Institute
Japan Science and Technology Agency
Japan Science and Technology Agency
International Classes:
C12N9/90; G01N33/50; A61K45/00; A61P3/04; A61P25/00; A61P25/20; A61P37/08; A61P43/00; C12N9/99; C12Q1/527; G01N33/15
Domestic Patent References:
| JP9322773A |
Foreign References:
| EP0633534A1 |
Other References:
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Japanese Journal of Pharmacology,1998年 9月,Vol.78, No.1,pp.11-22
J. Biol. Chem.,2000年,Vol.275, No.40,pp.31239-31244
Biochem. J.,1998年,Vol.333, Pt.2,pp.317-325
Curr. Protein Pept. Sci.,2000年,Vol.1, No.1,pp.1-21
Cell,1997年,Vol.90, No.6,pp.1085-1095
Pediatric Research,1993年,Vol.34, No.1,pp.32-37,(abstract) Database BIOSIS [online](BIOLOGICAL ABSTRACTS INC);[検索日 2002.12.03] BIOSIS Acc. No.19
Prostaglandins,1977年,Vol.13, No.2,pp.209-218
Japanese Journal of Pharmacology,1998年 9月,Vol.78, No.1,pp.11-22
J. Biol. Chem.,2000年,Vol.275, No.40,pp.31239-31244
Biochem. J.,1998年,Vol.333, Pt.2,pp.317-325
Curr. Protein Pept. Sci.,2000年,Vol.1, No.1,pp.1-21
Cell,1997年,Vol.90, No.6,pp.1085-1095
Pediatric Research,1993年,Vol.34, No.1,pp.32-37,(abstract) Database BIOSIS [online](BIOLOGICAL ABSTRACTS INC);[検索日 2002.12.03] BIOSIS Acc. No.19
Prostaglandins,1977年,Vol.13, No.2,pp.209-218
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Toshio Ueda
Nagatoshi Shinagawa
Samejima Mutsumi
Toshio Ueda
Nagatoshi Shinagawa