Title:
所望エリスロポエチングリコアイソフォームプロフィールの製造方法
Document Type and Number:
Japanese Patent JP4109204
Kind Code:
B2
Abstract:
The present invention provides a process for the production of erythropoietin (EPO) with high purity and with a desired profile of EPO glycol-isoforms by using a combination of specific chromatographic steps in such a manner that the starting EPO glycol-isoform profile is changed or modified. The applied chromatographic steps includes at least (a) dye affinity chromatography, and (b) hydrophobic chromatography and/or (c) anion-exchange chromatography. In a preferred embodiment, the process further includes (d) gel filtration chromatography. The present invention also provides a process for the determination of erythropoietin (EPO) glycol-isoform profile in an EPO containing composition.
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Inventors:
Svetheina, Monica
Suvetsk, Yelka
Gantar-Xsera, Matia
Blink, Matyas
Frankie, Andrey
Suvetsk, Yelka
Gantar-Xsera, Matia
Blink, Matyas
Frankie, Andrey
Application Number:
JP2003578576A
Publication Date:
July 02, 2008
Filing Date:
March 26, 2002
Export Citation:
Assignee:
Let's Farmer's Medicals Day Day
International Classes:
C12P21/02; G01N33/483; B01J20/281; C07K1/18; C07K1/20; C07K1/22; C07K14/505; G01N27/447; G01N30/46; G01N30/88; G01N33/53; A61K38/00
Domestic Patent References:
| JP2001525338A | ||||
| JP10506924A | ||||
| JP2001511343A | ||||
| JP2001525342A |
Foreign References:
| WO1996035718A1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
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