Title:
凍結乾燥されたアルブミン非含有の組換え人血液凝固第8因子製剤
Document Type and Number:
Japanese Patent JP4119407
Kind Code:
B2
Abstract:
Disclosed is a lyophilized preparation of recombinant factor VIII used as a therapeutic preparation of hemophilia A. The lyophilized preparation of recombinant factor VIII is prepared by performing lyophilization using a mixture comprising 6 to 100 mM of L-arginine, 3.5 to 50 mM of L-isoleucine, and 10 to 100 mM of L-glutamic acid as a stabilizer for stabilizing the recombinant factor VIII which exhibits an unstable activity during lyophilization, rather than using human blood derived albumin.
Inventors:
Baeksanfun
Shin Young Nam
Kim jin man
Hojeuk
Yeongsik
Quon Ki Sung
Jeong Ji Hyun
Shin Young Nam
Kim jin man
Hojeuk
Yeongsik
Quon Ki Sung
Jeong Ji Hyun
Application Number:
JP2004236562A
Publication Date:
July 16, 2008
Filing Date:
August 16, 2004
Export Citation:
Assignee:
Green Cross Co., Ltd.
International Classes:
A61K38/16; A61K38/43; A61K9/19; A61K38/37; A61K47/18; A61P7/04; C07K14/755
Domestic Patent References:
| JP5502161A | ||||
| JP61022022A | ||||
| JP60089428A | ||||
| JP6510031A | ||||
| JP11513700A | ||||
| JP2001524090A | ||||
| JP10507182A | ||||
| JP63024951A |
Foreign References:
| WO1993022336A1 | ||||
| WO2000051629A1 | ||||
| WO1999010011A1 |
Attorney, Agent or Firm:
Yukio Ono
Horikawa Kaori
Horikawa Kaori