Title:
置換されたクロマニルスルホニル(チオ)尿素、それらの製法、医薬製剤におけるそれらの使用およびそれらを含有する医薬製剤
Document Type and Number:
Japanese Patent JP4132115
Kind Code:
B2
Abstract:
N-(4-Amidoalkyl-chroman-5-yl-sulphonyl)-urea or -thiourea derivatives of formula (I) and their salts are new. R1 = H, alkyl, alkoxy, F, Cl, Br, I, CF3, NH2, mono- or dialkylamino or alkylthio; R2a = H, Me or Et; R2b, R2d = H, Me or Et; or phenyl or benzyl (both optionally ring-substituted by 1-3 of halogen, Me, Et, OMe and OEt); R2c,R2e = H, Me or Et; R3 = H, alkyl, cycloalkyl, cycloalkylmethyl or CF3; n = 1 or 2; Z = O or S; A = phenyl (optionally substituted by 1-3 of halogen, Me, OMe, Et or OEt), a lactam residue of formula (a), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-per-hydro-isoquinolin-2-yl, 1-oxo-1,2-dihydro-iso-indol-2-yl or 1-oxo-per-hydro-iso-indol-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); unless specified otherwise alkyl moieties have 1-4C and cycloalkyl moieties 3-6C.
Inventors:
Heinrich Kristien Arngrat
Uwe Gerlach
Dieter Mania
Wolfgang Linz
Heinz Gegeline
Erik Claus
Peter Clause
Uwe Gerlach
Dieter Mania
Wolfgang Linz
Heinz Gegeline
Erik Claus
Peter Clause
Application Number:
JP33318096A
Publication Date:
August 13, 2008
Filing Date:
December 13, 1996
Export Citation:
Assignee:
Hoechst Gesellschaft Mito Beschlenktel Haftung
International Classes:
C07D311/58; A61K31/35; A61K31/352; A61K31/353; A61K31/40; A61K31/4015; A61K31/4025; A61K31/4412; A61K31/443; A61K31/445; A61P9/00; A61P9/04; A61P9/06; A61P9/10; C07D311/64; C07D311/70; C07D405/12
Domestic Patent References:
| JP3066681A | ||||
| JP7304782A |
Foreign References:
| WO1995013272A1 | ||||
| WO1995002589A1 |
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura