Title:
置換されたクロマン誘導体
Document Type and Number:
Japanese Patent JP4150161
Kind Code:
B2
Abstract:
The present invention relates to new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives having the formula (I) wherein X is N; Y is NR2CH2, CH2NR2, NR2CO, CONR2, NR2SO2 or NR2CONR2 wherein R2 is H or C1-C6 alkyl; R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycoalkyl or (CH2)n-aryl, wherein aryl is a heteromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R4 and/or R5; and n is 0-4; as (R)-enantiomers, (S)-enantiomers or racemates in the form of a free base or a pharmaceutically acceptable salt or solvate thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds.
Inventors:
Stefan Bellui
Martin Nurehu
Svante Ross
Seto-Olov Tourberg
Martin Nurehu
Svante Ross
Seto-Olov Tourberg
Application Number:
JP2000511761A
Publication Date:
September 17, 2008
Filing Date:
September 09, 1998
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D311/58; A61K31/496; A61K31/5377; A61K31/551; A61P1/14; A61P3/04; A61P9/08; A61P9/12; A61P13/02; A61P15/00; A61P15/10; A61P25/00; A61P25/06; A61P25/16; A61P25/18; A61P25/22; A61P25/28; A61P25/32; A61P25/34; A61P29/00; C07D405/12
Foreign References:
| US5500425 |
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa