Title:
グリコサミノグリカン―アンチトロンビンIII/ヘパリン補因子II結合体
Document Type and Number:
Japanese Patent JP4166275
Kind Code:
B2
Abstract:
Novel conjugates of glycosaminoglycans, particularly heparin and dermatan sulfate, and amine containing species and therapeutic uses thereof are described. In particular, mild methods of conjugating heparins to proteins, such as antithrombin III and heparin cofactor II, which provide covalent conjugates which retain maximal biological activity are described. Uses of these conjugates to prevent thrombogenesis, in particular in lung airways, such as found in infant and adult respiratory distress syndrome are also described.
Inventors:
Berry,leslie
Andrew, Moureen
Andrew, Moureen
Application Number:
JP52003397A
Publication Date:
October 15, 2008
Filing Date:
November 29, 1996
Export Citation:
Assignee:
Hamilton Civic Hospitals Research Development, Incorporated
International Classes:
C07K14/745; A61F2/06; A61K31/00; A61K31/715; A61K31/726; A61K31/727; A61K47/48; A61L27/20; A61L33/00; A61P7/00; A61P7/02; A61P11/00; C07K14/81
Domestic Patent References:
| JP54025802A |
Foreign References:
| US4689323 | ||||
| EP0098814A1 |
Other References:
生体材料, 1995年, Vol.13, No.1, pp.21-25
Thrombosis Research, 1978年, Vol.13, pp.655-670
Journal of Cardiovascular and Pharmacology, 1985年, Vol.7, No.suppl.3, pp.S191-S205
Thrombosis Research, 1978年, Vol.13, pp.655-670
Journal of Cardiovascular and Pharmacology, 1985年, Vol.7, No.suppl.3, pp.S191-S205
Attorney, Agent or Firm:
Hidesaku Yamamoto
Previous Patent: ＤＲＡＭリフレッシュ方法
Next Patent: CONTROLLING DEVICE FOR NUMBER OF REVOLUTIONS OF ROTARY SORTING CYLINDER IN RICE HUSKING SORTING MACH...
Next Patent: CONTROLLING DEVICE FOR NUMBER OF REVOLUTIONS OF ROTARY SORTING CYLINDER IN RICE HUSKING SORTING MACH...