Title:
E型肝炎ウイルス抗原およびその使用
Document Type and Number:
Japanese Patent JP4237747
Kind Code:
B2
Abstract:
Antigens are provided which are derived from the enterically transmitted non-A/non-B viral hepatitis agent, known as hepatitis E virus (HEV). The HEV antigens and in particular, soluble species of the capsid protein encoded by the carboxy terminal region of HEV ORF2, are immunoreactive with sera from individuals infected with HEV. In one embodiment, these antigens may be produced by a baculovirus expression vector and form virus-like particles (VLPs). The antigens are useful as diagnostic reagents in diagnostic methods and kits for determining infection of an individual with HEV. The antigens are also useful in vaccine compositions effective in methods for preventing HEV infection.
Inventors:
Thomas Earl. First
C. Patrick McQuaty
Patrice Au. Yarbo
Efan Zhang
C. Patrick McQuaty
Patrice Au. Yarbo
Efan Zhang
Application Number:
JP2005354138A
Publication Date:
March 11, 2009
Filing Date:
December 07, 2005
Export Citation:
Assignee:
Genelabs Technologies, Inc.
International Classes:
C12N15/09; G01N33/576; A61K38/00; A61K39/29; A61K48/00; A61P31/12; A61P31/20; C07K14/005; C07K14/08; C07K16/10; C12N15/00; C12N15/40; C12P21/02; C12Q1/70; A61K39/00; C12R1/91; C12R1/92
Domestic Patent References:
| JP11500001A |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita