Title:
核酸リガンド
Document Type and Number:
Japanese Patent JP4276272
Kind Code:
B2
Abstract:
A new class of nucleic acid compounds, referred to as nucleic acid antibodies, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the ligand components of the nucleic acid antibodies are identified by the method of the invention referred to as the Systematic Evolution of Ligands by Exponential Enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.
Inventors:
Gold, rally
Tuark, craig
Tuark, craig
Application Number:
JP2007075076A
Publication Date:
June 10, 2009
Filing Date:
March 22, 2007
Export Citation:
Assignee:
Guilleed Sciences, Inc.
International Classes:
C12Q1/68; A61K31/70; A61K47/48; C07H15/12; C07H19/06; C07H19/10; C07H21/00; C07H21/02; C07H21/04; C07K5/00; C07K14/00; C07K16/44; C12N9/12; C12N15/09; C12N15/10; C12N15/115; C12P19/34; C12Q1/37; C12Q1/70; G01N33/48; G01N33/53; G01N33/531; G01N33/532; G01N33/535; G01N33/566; G01N33/569; G01N33/68; G01N33/76; C07B61/00; F02B75/02
Other References:
Nucleic Acid Research Vol.17 No.10 (1989) pp.3645-3653
Proc. Natl. Acad. Sci. USA, Vol.63 (1969) pp.458-464
Proc. Natl. Acad. Sci. USA, Vol.85 (1988) pp.7942-7946
Biochemistry, Vol.26, No.6 (1987) pp.1563-1568
Biochemistry, Vol.22, No.11 (1983) pp.2601-2610
Proc. Natl. Acad. Sci. USA, Vol.63 (1969) pp.458-464
Proc. Natl. Acad. Sci. USA, Vol.85 (1988) pp.7942-7946
Biochemistry, Vol.26, No.6 (1987) pp.1563-1568
Biochemistry, Vol.22, No.11 (1983) pp.2601-2610
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri