抗アテローム性動脈硬化剤としてのアルキル―4―シリル―フェノールおよびそのエステル

Japanese Patent JP4309473

B2

This invention relates to compounds of the formulaendently C1-C6 alkyl; R2, R3 and R4 are each independently hydrogen or C1-C6 alkyl; R is hydrogen or -C(O)-(CH2)m-Q wherein Q is hydrogen or -COOH and m is an integer 1, 2, 3 or 4; Z is a thio, oxy or methylene group; A is a C1-C4 alkylene group; R5 and R7 are each independently a C1-C6 alkyl or -(CH2)n-(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or naphthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, halogen, trifluoromethyl, C1-C6 alkyl, or -NR8R9, wherein R8 and R9 are each independently hydrogen or C1-C6 alkyl; with the proviso that when R2 and at least one of R5 or R7 is C1-C6 alkyl, and Ar is not substituted with trifluoromethyl or -NR8R9, then R is -C(O)-(CH2)m-Q; or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as antioxidant chemical additives useful for preventing oxidative deterioration in organic materials.

Butsuyu, Stephen Jei
Chien, kim es
Edwards, Mikele Jei
Matt, The Ames E Genia
Parker, Logicer A
Vouar, Mark Jei
Light paul es
Yates, Mark Tay

JP53886297A

August 05, 2009

March 03, 1997

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Aventis Pharmaceuticals Incorporated

A61K31/695; C07F7/08; A61P3/06; A61P11/06; A61P19/02; A61P29/00; A61P37/00; A61P43/00; C07F7/10; C07F7/12

JP4230393A

Junji Yuda
Shoji Miwa
Noriyuki Takebayashi
Chika Takagi

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