Title:
TNF活性を有するフェニル-およびピリジル-ピペリジン類
Document Type and Number:
Japanese Patent JP4324381
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents a condensed heterocyclic group of formula (w) where W completes an aromatic or saturated 6-membered ring system comprising one or two nitrogen atoms or else an aromatic or saturated 5-membered ring system comprising a nitrogen, oxygen or sulfur atom which are optionally substituted, and to their N-oxides and to their salts or solvates, to the pharmaceutical compositions and the medicaments comprising them and to a process for their preparation.
Inventors:
Baroni, Marco
Bowery, Bernardo
Caseras, Pierre
Bowery, Bernardo
Caseras, Pierre
Application Number:
JP2002583414A
Publication Date:
September 02, 2009
Filing Date:
April 19, 2002
Export Citation:
Assignee:
Sanofi-Aventis
International Classes:
C07D401/06; A61K31/4433; A61K31/4436; A61K31/444; A61K31/4725; A61K31/498; A61P1/04; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P19/04; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P25/00; A61P25/04; A61P25/16; A61P25/20; A61P25/28; A61P27/02; A61P29/00; A61P29/02; A61P31/04; A61P31/06; A61P31/08; A61P31/12; A61P31/18; A61P31/20; A61P31/22; A61P33/06; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/14; C07D405/14; C07D409/14
Domestic Patent References:
| JP7258233A |
Foreign References:
| US4455422 |
Other References:
DUKIC,S. et al,Synthesis and dopaminergic properties of 3- and 4-substituted 1-{2-[5-(1H-benzimidazole-2-thione)]ethyl}piperidines and related compounds,Archiv der Pharmazie(Weinheim, Germany),1997年,Vol.330, No.1/2,p.25-28
Attorney, Agent or Firm:
Shintaro Nogawa