Title:
可溶性トロンボモジュリン高濃度含有製剤
Document Type and Number:
Japanese Patent JP4340540
Kind Code:
B2
Abstract:
In preparing a high-concentrated soluble thrombomodulin-containing solution having a concentration of 10 mg/mL or above, foam-inhibiting effect can be attained by any means selected from among (a) allowing the presence of a nonionic surfactant, benzyl alcohol or chlorobutanol, (b) an inner wall of the container to be used in dissolving the soluble thrombomodulin-containing freeze-dried preparation is coated with silicone, and (c) a pressure in the container to be used in dissolving the soluble thrombomodulin-containing freeze-dried preparation is kept at a reduced pressure. Further, a soluble thrombomodulin freeze-dried preparation excellent in stability is also provided which can be dissolved in 0.1 mL to 2 mL of aqueous solution for dissolution to prepare a high-concentrated soluble thrombomodulin-containing solution having a concentration of 10 mg/mL or above and exhibiting an osmotic pressure ratio of 0.5 to 2.0 at the time of resolution.
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Inventors:
Fumihide Nishio
Application Number:
JP2003561630A
Publication Date:
October 07, 2009
Filing Date:
January 17, 2003
Export Citation:
Assignee:
Asahi Kasei Pharma Co., Ltd.
International Classes:
A61K38/00; A61K9/08; A61K9/19; A61K38/36; A61K47/10; A61K47/14; A61K47/34; A61P1/16; A61P3/10; A61P7/00; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P15/00; A61K47/18
Domestic Patent References:
| JP62289529A | ||||
| JP2000026309A | ||||
| JP10072364A | ||||
| JP6321805A | ||||
| JP9124481A | ||||
| JP2001519770A | ||||
| JP55048064A |
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes