Title:
所定の吸入ルートによるアルプラゾラム、エスタゾラム、ミダゾラムまたはトリアゾラムの送出
Document Type and Number:
Japanese Patent JP4357842
Kind Code:
B2
Abstract:
The present invention relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of alprazolam, estazolam, midazolam or triazolam, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route is provided which comprises: a) a thin coating of an alprazolam, estazolam, midazolam, or triazolam composition and b) a device for dispensing said thin coating as a condensation aerosol.
Inventors:
Rabinowits Joshua, Dee.
Zafaroni, Alegend Rocy.
Zafaroni, Alegend Rocy.
Application Number:
JP2002590937A
Publication Date:
November 04, 2009
Filing Date:
May 22, 2002
Export Citation:
Assignee:
Alec The Pharmaceuticals, Incorporated
International Classes:
A61K31/5517; A61K9/00; A61K9/12; A61K31/00; A61K31/137; A61K31/138; A61K31/165; A61K31/192; A61K31/216; A61K31/27; A61K31/404; A61K31/405; A61K31/407; A61K31/4196; A61K31/422; A61K31/423; A61K31/437; A61K31/473; A61K31/49; A61K31/495; A61K31/496; A61K31/4985; A61K31/501; A61K31/519; A61K31/53; A61K31/551; A61K47/48; A61P25/20; A61P25/22; F24V30/00
Domestic Patent References:
| JP2729525B2 | ||||
| JP2004509141A |
Other References:
British Jouranl of Anaesthesia,1998年,Vol.80,p.562-567
J.Oral.Maxillofac.Surg.,1992年,Vol.50,p.989-997
横地 明,1 各種吸入用粒子発生法とその特徴,NIRS-M(National Inst. of Radiologial Sciences,1991年,p.3-12
J.Oral.Maxillofac.Surg.,1992年,Vol.50,p.989-997
横地 明,1 各種吸入用粒子発生法とその特徴,NIRS-M(National Inst. of Radiologial Sciences,1991年,p.3-12
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri