Title:
プロプラノロールの時限徐放性多粒子剤型
Document Type and Number:
Japanese Patent JP4369752
Kind Code:
B2
Abstract:
A unit dosage form, such as a capsule or the like for delivering drugs into the body in a circadian release fashion, is comprising of one or more populations of propranolol-containing particles (beads, pellets, granules, etc.). Each bead population exhibits a pre-designed rapid or sustained release profile with or without a predetermined lag time of 3 to 5 hours. Such a circadian rhythm release cardiovascular drug delivery system is designed to provide a plasma concentration-time profile, which varies according to physiological need during the day, i.e., mimicking the circadian rhythm and severity/manifestation of a cardiovascular disease, predicted based on pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.
Inventors:
Purcell Philip Jay
Venkatesh Gopiem
Vishnu Pad Krishna S
Venkatesh Gopiem
Vishnu Pad Krishna S
Application Number:
JP2003532041A
Publication Date:
November 25, 2009
Filing Date:
October 02, 2002
Export Citation:
Assignee:
Eurand Inc.
International Classes:
A61K9/14; A61K31/138; A61K9/50; A61K9/52; A61K9/54; A61K9/62; A61K47/14; A61K47/32; A61K47/34; A61K47/38; A61K47/44; A61P9/00
Domestic Patent References:
| JP8175978A | ||||
| JP62246513A | ||||
| JP2289512A |
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama