Title:
CB1作動活性、CB1部分作動活性またはCB1-拮抗活性を有する1H-イミダゾール誘導体
Document Type and Number:
Japanese Patent JP4393869
Kind Code:
B2
Abstract:
The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I), wherein R and R1-R4 have the meanings given in the specification.
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Inventors:
Kruze, Cornelis G
Lange, Josephus H.M.
Heremance, Arnoldus HJ
Ban Stuibenberg, Hermann H
Lange, Josephus H.M.
Heremance, Arnoldus HJ
Ban Stuibenberg, Hermann H
Application Number:
JP2003530667A
Publication Date:
January 06, 2010
Filing Date:
September 17, 2002
Export Citation:
Assignee:
Solvay Pharmaceuticals B.V.
International Classes:
C07D233/90; A61K31/4164; A61K31/4178; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4725; A61K31/5377; A61K31/55; A61P1/04; A61P1/08; A61P1/12; A61P3/04; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/06; A61P31/04; A61P35/00; A61P43/00; C07C257/18; C07D295/30; C07D401/04; C07D401/06; C07D403/04; C07D403/12; C07D405/04; C07D405/12
Domestic Patent References:
| JP10503211A |
Foreign References:
| WO2000069848A1 | ||||
| WO2000046209A1 |
Other References:
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実験化学講座20有機合成II-アルコール・アミン-,1992年,第4版,p.p. 333-338
Tetrahedron Letters,1988年,vol. 29, No. 36,p.p. 4607-4610
Chem. Pharm. Bull.,1999年,vol. 47, No. 6,p.p. 857-868
J. Med. Chem.,2000年,vol. 43, No. 16,p.p. 3168-3185
新実験化学講座14-有機化合物の合成と反応IV-,1978年,p.p. 2192-2193
Attorney, Agent or Firm:
Patent business corporation Odashima patent office