Title:
試料を照射するシステムおよび方法
Document Type and Number:
Japanese Patent JP4436132
Kind Code:
B2
Abstract:
Method and system for footprinting a nucleic acid molecule. A sample consists of a nucleic acid molecule in an environment in which -OH radicals are generated when the environment is irradiated with an X-ray beam having an intensity less than 109 photons sec-1 mm-2 for an amount of time less than 1,000 msec. The sample is then irradiated with an X-ray beam having an intensity less than 109 photons sec-1 mm-2 for an amount of time less than 1,000 msec so as to generate -OH radicals in the environment. Fragmentation of the nucleic acid molecule is then detected.
Inventors:
Egret, Irito
Hen, Arnon
Halfon, Jacob
Hen, Arnon
Halfon, Jacob
Application Number:
JP2003547993A
Publication Date:
March 24, 2010
Filing Date:
October 07, 2002
Export Citation:
Assignee:
Yeda Research and Development Company Limited
International Classes:
G01N33/50; G01N23/02; G01N33/00; G01T1/00; G01T7/00; G21K5/02; G21K5/08; G01T; H01J
Domestic Patent References:
| JP2003502036A | ||||
| JP10300900A |
Other References:
Bianca Sclavi et.al.,Time-resolved Synchrotoron X-ray2 ”Footprinting", a New Approach to the Study of Nucleic Acid Structure and Function:Application to Protein-DNA Interactions and RNA Folding,JORNAL OF MOLECULAR BIOLOGY,1997年 3月 3日,266(1),P.144-159
Radiation Research,1997年,Vol.148, No.4,P.317-324
Radiation Research,1997年,Vol.148, No.4,P.317-324
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro