Title:
半合成法及び新規の化合物
Document Type and Number:
Japanese Patent JP4445136
Kind Code:
B2
Abstract:
Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from -H, -OH or -OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both -H ozone is -H and the other is -OH, -OCH3 or -OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from -H or -OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.
Inventors:
Carmen Cuevas
Marta Perez
Andres Frances
Carolina Fernandez
Jose Luis Chicharo
Pilar Gallego
Maria Sarsuelo
Fernando de la Carge
Ignacio Manzanares
Marta Perez
Andres Frances
Carolina Fernandez
Jose Luis Chicharo
Pilar Gallego
Maria Sarsuelo
Fernando de la Carge
Ignacio Manzanares
Application Number:
JP2000618279A
Publication Date:
April 07, 2010
Filing Date:
May 15, 2000
Export Citation:
Assignee:
Pharma Mar Sociedad Anonima
International Classes:
C07D471/18; A61K31/4995; C07D487/18; A61K35/00; A61P31/04; A61P35/00; C07D221/00; C07D241/00; C07D291/00; C07D317/00; C07D471/22; C07D491/22; C07D515/00; C07D515/22; C07D
Domestic Patent References:
JP60084288A | ||||
JP59225189A |
Foreign References:
US5721362 |
Attorney, Agent or Firm:
Masatake Shiga
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro