Title:
フラビウイルス感染症の予防のための核酸ワクチン
Document Type and Number:
Japanese Patent JP4448281
Kind Code:
B2
Abstract:
The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus or of a chimeric immunogenic flavivirus antigen comprising sequence from more than one flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection
Inventors:
Changwon-Jen Jay.
Application Number:
JP2002579516A
Publication Date:
April 07, 2010
Filing Date:
April 04, 2002
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C12N15/09; A61K31/711; A61K39/00; A61K39/12; A61K48/00; A61P31/14; C07K14/18; C07K16/10; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/40; C12Q1/70; G01N33/53; G01N33/569
Domestic Patent References:
| JP7265093A | ||||
| JP3148066A | ||||
| JP1501203A |
Foreign References:
| WO1998037911A1 | ||||
| WO1999063095A1 |
Other References:
J. Virol.,2000年,vol.74, no.9,p.4244-4252
Proc. Natl. Acad. Sci. U.S.A,1992年,vol.89, no.21,p.10532-10536
J. Virol.,1998年,vol.72, no.6,p.4925-4930
J. Virol.,1997年,vol.71, no.12,p.9563-9569
Virology,1998年,vol.250, no.1,p.151-163
Vaccine,1997年,vol.15, no.5,p.547-552
Arch. Virol.,1996年,vol.141, no.3-4,p.743-749
Proc. Natl. Acad. Sci. U.S.A,1992年,vol.89, no.21,p.10532-10536
J. Virol.,1998年,vol.72, no.6,p.4925-4930
J. Virol.,1997年,vol.71, no.12,p.9563-9569
Virology,1998年,vol.250, no.1,p.151-163
Vaccine,1997年,vol.15, no.5,p.547-552
Arch. Virol.,1996年,vol.141, no.3-4,p.743-749
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita