Title:
5-フェニルピリミジン類、その製造方法、これらを含む組成物及びこれらの使用
Document Type and Number:
Japanese Patent JP4450625
Kind Code:
B2
Abstract:
5-Phenylpyrimidines of the formula I in which the substituents and the index are as defined below: R1,R2 are hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, and R1 and R2 together with the nitrogen atom to which they are attached may also form a saturated or unsaturated ring which may be interrupted by an ether, thio, sulfoxyl or sulfonyl group and may be substituted by one to four groups Ra and/or Rb; R3 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy or alkenyloxy; R4 is hydrogen, halogen, cyano, hydroxyl, mercapto, azido, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, alkenyloxy, alkynyloxy, haloalkoxy, alkylthio, alkenylthio, alkynylthio, haloalkylthio, -ON-CRaRb, -CRc-NORa, -NRcN-CRaRb, -NRaRb, -NRcNRaRb, -NORa, -NRcC(-NRc')NRaRb, -NRcC(-O)NRaRb, -NRaC(-O)Rc, -NRaC(-NORc)Rc', -OC(-O)Rc, -C(-NORc)NRaRb, -CRc(-NNRaRb), -C(-O)NRaRb or -C(-O)Rc; in which Ra, Rb and Rc are as defined in the description; X is halogen, alkyl, alkoxy or haloalkyl; and m is an integer from 1 to 5; processes for preparing these compounds, compositions comprising them and their use for controlling harmful fungi are described.
Inventors:
Gypsar, andreas
Grotte, thomas
Schwegler, Anya
Reinheimer, Joachim
Civek, Frank
Tormo e Brasco, Jordi
Rose, ingo
Scheffer, Peter
Gerber, marx
Gran Menos, Vasilios
Mueller, Bernd
Amermann, Eberhard
Stratman, Siegfried
Lorenz, Giesella
Steel, Reinhard
Grotte, thomas
Schwegler, Anya
Reinheimer, Joachim
Civek, Frank
Tormo e Brasco, Jordi
Rose, ingo
Scheffer, Peter
Gerber, marx
Gran Menos, Vasilios
Mueller, Bernd
Amermann, Eberhard
Stratman, Siegfried
Lorenz, Giesella
Steel, Reinhard
Application Number:
JP2003545630A
Publication Date:
April 14, 2010
Filing Date:
November 15, 2002
Export Citation:
Assignee:
BASF SE
International Classes:
A01N43/54; C07D239/42; A01P3/00; C07D239/46; C07D239/47; C07D239/48; C07D239/52; C07D401/06; C07D401/14; C07D403/12
Domestic Patent References:
| JP2202876A | ||||
| JP8283246A |
Foreign References:
| US2418548 | ||||
| US5250530 |
Other References:
B. R. Baker et al.,An antimalarial alkaloid from hydrangea. XVIII. Derivatives of 4-pyrimidone,Journal of Organic Chemistry,1953年,Vol.18, No.2,p.133-137
Z. Budesinsky et al.,5-Arylpyrimidine II. 4,6-Disubstituierte 5-phenylpyrimidine,Collection of Czechoslovak Chemical Communications,1965年,Vol.30,p.3730-3743
Nancy Acton et al.,Characterization and antimalarial activity of four acetylated pyrimidine,Heterocycles,1980年,Vol.14, No.4,p.471-476
Chen Shicong et al.,Synthesis and schistosomicidal activity of fluoroacetamides-a new class of antischistosomal agents,Yaoxue Xuebao,1982年,Vol.17, No.9,p.674-681
小山鷹二ら,Benzylcarbonyl化合物とFormamideとの反応(第3報),薬学雑誌,1969年,Vol.89, No.10,p.1334-1337
G. C. Tsatsaronis et al.,Synthesis of 4-substituted 5-p-chlorophenylpyrimidines,Journal of the Royal Netherlands Chemical Society,1971年,Vol.90,p.584-586
小山鷹二ら,Benzylcarbonyl化合物とFormamideとの反応.VIII. m-位にMethyl基を有するα-Acylphenylacetonitrileの反応,薬学雑誌,1972年,Vol.92, No.10,p.1233-1236
John A. Hyatt et al.,Photochemistry in the Tetrazole-Azidoazomethine System. A Facile Synthesis of 9H-Pyrimido[4,5-b]indoles,The Journal of Organic Chemistry,1972年,Vol.37, No.21,p.3216-3220
S. A. Lang, Jr. et al.,4-Amino-5-arylpyrimidines as Antiinflammatory Agents,Journal of Medicinal Chemistry,1975年,Vol.18, No.6,p.623-625
Alfred Kreutzberger et al.,5-Substituierte 4-Aminopyrimidine durch Aminomethinylierung von Acetonitrilen,Justus Liebigs Annalen der Chemie,1977年,p.537-544
Takashi Hirota et al.,Polycyclic N-Hetero Compounds. XVI. Reactions of Benzyl Ketones with Formamide or Acetamide,Chemical & Pharmaceutical Bulletin,1978年,Vol.26, No.1,p.245-250
Tsatsaronis, G. et al.,Synthesis of 4-substituted-5-p-chlorophenylpyrimidines,Chemical Abstracts,1976年,Vol.85,78076d
Z. Budesinsky et al.,5-Arylpyrimidine II. 4,6-Disubstituierte 5-phenylpyrimidine,Collection of Czechoslovak Chemical Communications,1965年,Vol.30,p.3730-3743
Nancy Acton et al.,Characterization and antimalarial activity of four acetylated pyrimidine,Heterocycles,1980年,Vol.14, No.4,p.471-476
Chen Shicong et al.,Synthesis and schistosomicidal activity of fluoroacetamides-a new class of antischistosomal agents,Yaoxue Xuebao,1982年,Vol.17, No.9,p.674-681
小山鷹二ら,Benzylcarbonyl化合物とFormamideとの反応(第3報),薬学雑誌,1969年,Vol.89, No.10,p.1334-1337
G. C. Tsatsaronis et al.,Synthesis of 4-substituted 5-p-chlorophenylpyrimidines,Journal of the Royal Netherlands Chemical Society,1971年,Vol.90,p.584-586
小山鷹二ら,Benzylcarbonyl化合物とFormamideとの反応.VIII. m-位にMethyl基を有するα-Acylphenylacetonitrileの反応,薬学雑誌,1972年,Vol.92, No.10,p.1233-1236
John A. Hyatt et al.,Photochemistry in the Tetrazole-Azidoazomethine System. A Facile Synthesis of 9H-Pyrimido[4,5-b]indoles,The Journal of Organic Chemistry,1972年,Vol.37, No.21,p.3216-3220
S. A. Lang, Jr. et al.,4-Amino-5-arylpyrimidines as Antiinflammatory Agents,Journal of Medicinal Chemistry,1975年,Vol.18, No.6,p.623-625
Alfred Kreutzberger et al.,5-Substituierte 4-Aminopyrimidine durch Aminomethinylierung von Acetonitrilen,Justus Liebigs Annalen der Chemie,1977年,p.537-544
Takashi Hirota et al.,Polycyclic N-Hetero Compounds. XVI. Reactions of Benzyl Ketones with Formamide or Acetamide,Chemical & Pharmaceutical Bulletin,1978年,Vol.26, No.1,p.245-250
Tsatsaronis, G. et al.,Synthesis of 4-substituted-5-p-chlorophenylpyrimidines,Chemical Abstracts,1976年,Vol.85,78076d
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita