一酸化窒素の生成を阻害するテトラサイクリン化合物の使用方法

Japanese Patent JP4451930

B2

The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.

WO/2003/070231	ANTIBACTERIAL COMPOSITIONS
WO/1998/037188	OLIGONUCLEOTIDES SPECIFIC FOR THE $i(marORAB) OPERON
WO/2008/021788	POLYAMINE COMPOUNDS

Amin Ashok Earl
Abramson Stephen Bee
Golub Lone M
Ramamarty Nungavaram S
McNamara Thomas F
Greenwald Robert A
Tractman howard

JP51173598A

April 14, 2010

August 21, 1997

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The Research Foundation of State University of New York
Hospital For Joint Diseases

A61K31/65; A61K31/573; A61P13/12; A61P19/02; A61P29/00; A61P43/00

JP4178359A
JP6122663A
JP6192103A
JP3227931A

Minoru Nakamura
Fumiaki Otsuka
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo

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