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Title:
チエノピリミジンジオンおよび自己免疫疾患調節におけるその使用
Document Type and Number:
Japanese Patent JP4456364
Kind Code:
B2
Abstract:
The invention relates to a compound of formula (1): in which R1 and R2 each independently represent a C1-6alkyl, C3-6alkenyl, C3-6cycloalkylC1-3alkyl or C3-6cycloalkyl; each of which is optionally substituted by 1 to 3 halogen atoms; R3 is isoxazolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is -CO- or -C(R4)(R5)- in which R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system in which up to 4 ring atoms may be heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.

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Inventors:
Rachel Hulwen Reynolds
Anthony Howard Ingoal
Luxana Tasnieme Rasuru
Simon David Guile
Martin Edward Cooper
Application Number:
JP2003517059A
Publication Date:
April 28, 2010
Filing Date:
July 24, 2002
Export Citation:
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Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D495/04; A61K31/519; A61P1/00; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/08; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P27/16; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D519/00
Domestic Patent References:
JP8073457A
JP2003531910A
Foreign References:
WO1998054190A1
WO2000012514A1
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima



 
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