N-(4-フルオロフエニル)-N-(1-メチルエチル)-2-[(5-(トリフルオロメチル)-1,3,4-チアジアゾール-2-イル)-オキシ]-アセトアミドの製造方法

Title:

N-(4-フルオロフエニル)-N-(1-メチルエチル)-2-[(5-(トリフルオロメチル)-1,3,4-チアジアゾール-2-イル)-オキシ]-アセトアミドの製造方法

Document Type and Number:

Japanese Patent JP4472041

Kind Code:

B2

Abstract:

The present invention relates to a process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide, which process includes the steps of reacting 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4,-thiadiazole with N-(4-fluorophenyl)-N-(1-methylethyl)-2-hydroxyacetamide in an aprotic, aromatic solvent with aqueous alkali to form an aqueous phase and an organic phase, separating the aqueous and organic phases and recovering the N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide from the organic phase. A preferred solvent and aqueous alkali are toluene and aqueous sodium hydroxide, respectively.

Inventors:

Vidyanasa A Prasad
Jaclyn M. Appulgate
Daniel M. Wathleski
Klaus Jeritzhi

Application Number:

JP34997498A

Publication Date:

June 02, 2010

Filing Date:

December 09, 1998

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