Title:
免疫細胞活性化を調節する作用剤およびその使用方法
Document Type and Number:
Japanese Patent JP4488740
Kind Code:
B2
Abstract:
Disclosed are methods for modulating an immune response including a method for inhibiting the interaction between a B7 polypeptide and a PD-1 ligand, the method comprising contacting an immune cell bearing a PD-1 ligand, or an immune cell bearing a B7 polypeptide, with an agent that inhibits the interaction between the PD-1 ligand and the B7 polypeptide. Such agents may be an anti-PD-1 ligand antibody or a small molecule. Also disclosed is a method for modulating an immune response comprising contacting an immune cell bearing the PD-1 ligand, or an immune cell bearing the PD-1 polypeptide, with an agent that inhibits interactions between the PD-1 ligand and the PD-1 polypeptide, without inhibiting interactions between the PD-1 ligand and a B7 polypeptide, to thereby modulate an immune response. The agent may be an anti-PD-1 ligand antibody or a small molecule.
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Inventors:
Gordon Jay Freeman
Arlene H Sharp
Janet Bourman
Didier Mandelbrot
Arlene H Sharp
Janet Bourman
Didier Mandelbrot
Application Number:
JP2003544216A
Publication Date:
June 23, 2010
Filing Date:
November 12, 2002
Export Citation:
Assignee:
DANA-FARBER CANCER INSTITUTE, INCORPORATED
International Classes:
C12Q1/02; A61K38/17; C07K14/705; C07K16/28; C12N15/09; G01N33/15; G01N33/50; G01N33/566; G01N33/68
Foreign References:
| WO2001014557A1 |
Other References:
The Journal of experimental medicine. 2000, Vol.192, No.7, p.1027-1034
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Samejima Mutsumi
Masahiro Nitta
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