サイトカイン阻害剤として有効なアミド誘導体

Japanese Patent JP4502509

B2

The invention concerns amide derivatives of the Formula (I)wherein R<3 >is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluoromethyl, cyano, (1-6C)alkyl, (1-6C)alkoxy, halogeno(1-6C)alkyl, hydroxy-(1-6C)alkyl, di-[(1-6C)alklyl]amino-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, (1-6)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, amino-2(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, aryl-(1-6C)alkoxy, heteroaryl, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyl-(1-6C)alkyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and R<2 >is a substituent such as hydroxy and halogeno; q is 0-4; and R<4 >includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

WO/2004/065351	AMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
WO/1994/000422	4-ACYLAMINOBENZAMIDES AND THEIR USE AS FUNGICIDES
WO/2003/006021	ALPHA-HYDROXYAMIDE STATINE DERIVATIVES FOR THE TREATMENT OF ALZH EIMER'S DISEASE

Brown, Doug Sutherland
Brown, George Robert

JP2000563615A

July 14, 2010

July 29, 1999

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AstraZeneca Activrag

C07C237/42; A61K31/165; C07D295/12; A61K31/167; A61K31/395; A61K31/402; A61K31/4025; A61K31/42; A61K31/435; A61K31/44; A61K31/4465; A61K31/451; A61K31/47; A61K31/496; A61K31/5375; A61K31/5377; A61K31/551; A61P1/04; A61P9/04; A61P11/06; A61P17/08; A61P19/02; A61P29/00; A61P31/18; A61P37/00; A61P43/00; C07C231/02; C07C231/10; C07C235/56; C07C255/57; C07D207/08; C07D207/12; C07D211/22; C07D211/34; C07D211/46; C07D213/82; C07D215/48; C07D223/08; C07D243/08; C07D261/08; C07D261/18; C07D277/24; C07D295/13; C07D295/135; C07D295/14; C07D295/155; C07D317/68; C07D401/04; C07D413/12

JP62054763A
JP4177350A
JP9118658A
JP9124571A
JP10502630A
JP2001517620A

WO1997003967A1
WO1999024404A1
US1903899
US1909960
US3328410
NL6514409A

Journal of the Chemical Society,1956年,p.3739-3744
Journal of Medicinal Chemistry,1996年,39(17),p.3343-3356
Bull. trav. inst. pharm. etat,1926年,(No. 4),p.1-12

Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita

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