不斉水素化によるキラルなベータアミノ酸誘導体の製造方法

Title:

不斉水素化によるキラルなベータアミノ酸誘導体の製造方法

Document Type and Number:

Japanese Patent JP4503594

Kind Code:

B2

Abstract:

The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.

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Inventors:

Xiao
Armstrong, Youdiff Day, The Third
Crusca, Chain Davryu
Niorito, Eugenia
Rivera, Nero Earl
Sun, Yong Kui
Rothner, Thorsten

Application Number:

JP2006507177A

Publication Date:

July 14, 2010

Filing Date:

March 15, 2004

Export Citation:

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Assignee:

Merck Sharp End Dome Corporation

International Classes:

C07C231/12; B01J31/22; B01J31/24; C07C227/16; C07C237/20; C07D213/64; C07D487/04; C07B53/00; C07B61/00

Domestic Patent References:

JP2005518339A
JP2002265425A
JP6041171A
JP2003523990A
JP2004075684A

Foreign References:

WO2003004498A1

Attorney, Agent or Firm:

Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

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