Title:
シクロペンテンニトリル誘導体の製造方法
Document Type and Number:
Japanese Patent JP4503596
Kind Code:
B2
Abstract:
[PROBLEMS] To provide a process for the synthesis of cyclopentenenitrile derivatives through conjugate addition of a nitrile derivative to an ±,²-unsaturated ketone whereby cyclopentenenitrile derivatives, particularly those capable of optical resolution, can be obtained in high yield without expensive reagents or compounds in a decreased number of steps. [MEANS FOR SOLVING PROBLEMS] A novel process for the production of cyclopentenenitrile derivatives in high yield, which comprises trapping a compound obtained by conjugate addition of a 4-alkoxy-3-butenenitrile which may have alkyl or allyl at the ±-position (e.g., 4-methoxy-3-butenenitrile) to an ±,²-unsaturated ketone as an enol ester with acetic anhydride, chlorocarbonic ester, or the like and treating the enol ester with a strong acid or the like to form a five-membered ring.
Inventors:
Miyashita Masaaki
Keiji Tanino
Tomonata Keiei
Yasuhiro Shiina
Keiji Tanino
Tomonata Keiei
Yasuhiro Shiina
Application Number:
JP2006510773A
Publication Date:
July 14, 2010
Filing Date:
March 07, 2005
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
C07C253/30; C07B53/00; C07B57/00; C07C255/47; C12P13/00; C12P41/00
Other References:
J. Am. Chem. Soc.,(1990), Vol.112, No.25,p.9401-9403
Attorney, Agent or Firm:
Norio Saeki
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