Title:
癌に特異的に作用する細胞死誘導融合遺伝子及びその遺伝子産物
Document Type and Number:
Japanese Patent JP4524359
Kind Code:
B2
Abstract:
The present invention provides a protein having a potent cell-death inducing activity that is, a fused protein is in which a modified Bax protein fused with GFP at the N-terminus and is further fused with a homing signal peptide having a homing activity specific for endothelial cells in tumor angiogenesis; a gene coding the fused protein; and a cancer cell growth inhibitor containing the fused protein. Namely, a fused gene containing a cell death-inducing gene acting specially on cancer tissue, which is a fused gene having a gene encoding a homing signal peptide sequence specific for endothelial cells undergoing angiogenesis, a gene encoding a green fluorescent protein (GFP) and a gene encoding ”NBax protein, which is human Bax with a deletion of the N-terminal sequence containing the BH3 domain in this order, and a fusion protein encoded by the fused gene.
More Like This:
| WO/2003/086380 | PTX3 GENE EXPRESSION SUPPRESSING METHOD |
| WO/1992/014829 | VIRAL PARTICLES HAVING ALTERED HOST RANGE |
| JP2003526330 | [Title of the Invention] Neutrokine-α and Neutrokine-α splice variants |
Inventors:
Shigeo Ohta
Aso Sadamitsu
Aso Sadamitsu
Application Number:
JP2005504065A
Publication Date:
August 18, 2010
Filing Date:
March 23, 2004
Export Citation:
Assignee:
Nippon Medical School
International Classes:
C12N15/09; A61K38/00; A61P35/00; A61P43/00; C07K7/06; C07K14/47; C07K19/00; C12P21/02
Domestic Patent References:
| JP2002355034A | 2002-12-10 | |||
| JP2002535258A | 2002-10-22 |
Foreign References:
| WO2001053342A1 | 2001-07-26 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Natsuo Tanaka
Ishii Teiji
Satoshi Fujita
Natsuo Tanaka