Title:
プロテインキナーゼインヒビターとしての5-(2-アミノピリミジン-4-イル)ベンズイソキサゾール
Document Type and Number:
Japanese Patent JP4541695
Kind Code:
B2
Abstract:
Described herein are benzisoxazole compounds of formula I: or a pharmaceutically acceptable derivative or prodrug thereof, wherein A-B is N-O or O-N; Ar is an optionally substituted C5-10 aryl group; R1 is hydrogen or an optionally substituted group selected from C1-10 aliphatic, C5-10 aryl, C6-12 aralkyl, C3-10 heterocyclyl, or C4-12 heterocyclylalkyl; and T, n, R2 and R3 are as described in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 and JAK mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
Inventors:
Moon, Young Chohn
Green, jeremy
Davis, robert
Chokette, fat
Albert Pierce
Redebow, mark
Green, jeremy
Davis, robert
Chokette, fat
Albert Pierce
Redebow, mark
Application Number:
JP2003506273A
Publication Date:
September 08, 2010
Filing Date:
June 14, 2002
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07D413/04; A61K31/506; A61K31/5377; A61K31/551; A61K31/635; A61L27/00; A61P1/16; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P11/06; A61P19/02; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D413/14
Domestic Patent References:
| JP2003531103A | ||||
| JP2001500153A | ||||
| JP2003512358A | ||||
| JP2003528872A | ||||
| JP2003503354A | ||||
| JP2003503351A | ||||
| JP2003502406A | ||||
| JP2004513882A |
Foreign References:
| WO1997019065A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita