Title:
ミルナシプランの持続性放出を伴うガレヌス製剤形態
Document Type and Number:
Japanese Patent JP4549442
Kind Code:
B2
Abstract:
The invention concerns a pharmaceutical composition with prolonged release, for oral administration of a single daily dose of 60 to 140 mg of Milnacipran, having a multi-particulate form containing a plurality of microgranules each comprising an active microsphere containing a saccharose and/or starch nucleus of a size between 200 and 2000 mum and containing 150 to 1000 mum of Milnacipran and a binding agent, each microgranule being coated with a film having a base of at least one polymer insoluble in water but permeable to physiological liquids, of a thickness between 20 and 100 mum, the said pharmaceutical composition enabling an in vitro release corresponding to the following pattern: between 10 and 55% of the dose released in 2 hours, between 40 and 75% of the dose released in 4 hours, between 70 and 90% of the dose released in 8 hours, between 80 and 100% of the dose released in 12 hours.
Inventors:
Bruno, Piyar
Eric, Gute
Jean-Louis, Avan
Joel, Bugare
Eric, Gute
Jean-Louis, Avan
Joel, Bugare
Application Number:
JP51133798A
Publication Date:
September 22, 2010
Filing Date:
August 26, 1997
Export Citation:
Assignee:
Pierre, Fabre, Medicaman
International Classes:
A61K31/165; A61K9/16; A61K9/50; A61K9/52; A61K47/10; A61K47/32; A61K47/38; A61P25/24
Domestic Patent References:
| JP3002114A | ||||
| JP8003035A |
Other References:
新・薬剤学総論, 1987年, 改訂第3版, pp.163-164
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito