Title:
腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途
Document Type and Number:
Japanese Patent JP4575975
Kind Code:
B2
Abstract:
A purified antibody is disclosed which specifically binds a TRAIL receptor DR5, wherein said antibody:
a) has apoptosis-inducing activity in the absence of secondary crosslinking in target cells expressing DR5 in vitro, wherein the apoptosis-inducing activity in vitro is characterized by less than 70% target cell viability at an antibody concentration of 2.5 pg/ml;
b) has tumoricidal activity against tumor cells expressing DR5 in vivo; and
c) does not bind TRAIL receptor DR4, DcR1, or DcR2.
Inventors:
Butterfly ton
Kimihisa Ichikawa
Kimberly, Robert Pea.
Coopman, William Jay.
Kimihisa Ichikawa
Kimberly, Robert Pea.
Coopman, William Jay.
Application Number:
JP2008194948A
Publication Date:
November 04, 2010
Filing Date:
July 29, 2008
Export Citation:
Assignee:
The UAB Research Foundation
International Classes:
C12N15/02; A61K31/337; C12N15/09; A61K39/395; A61K45/06; A61P1/04; A61P3/10; A61P5/18; A61P7/06; A61P9/10; A61P13/12; A61P15/00; A61P17/00; A61P21/04; A61P25/00; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D305/14; C07H21/02; C07K16/00; C07K16/28; C07K16/30; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/00; C12N5/10; C12N15/00; C12P21/08; C12Q1/02
Foreign References:
| WO1990007861A1 |
Other References:
J. Immunol., (1999), 162, [5], p.2597-2605
J. Mol. Biol., (1992), 224, [2], p.487-499
Immunol. Today, (1993), 14, [6], p.243-246
J. Mol. Biol., (1992), 224, [2], p.487-499
Immunol. Today, (1993), 14, [6], p.243-246
Attorney, Agent or Firm:
Naomi Mae