Title:
感染症の治療のための弱毒化微生物
Document Type and Number:
Japanese Patent JP4583607
Kind Code:
B2
Abstract:
The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
Inventors:
Dougan, Gordon
Sant'Angelo, Joseph David
Holden, David William
Sea, Jackline Elizabeth
Hindru, zoo
Sant'Angelo, Joseph David
Holden, David William
Sea, Jackline Elizabeth
Hindru, zoo
Application Number:
JP2000616235A
Publication Date:
November 17, 2010
Filing Date:
May 09, 2000
Export Citation:
Assignee:
Emergent Product Development UK Limited
International Classes:
C12N15/09; A61K35/74; A61K39/112; A61K48/00; A61P31/04; A61P43/00; C07K14/255; C12N1/21; C12N15/31; C12R1/42
Foreign References:
| WO2000014240A1 |
Other References:
SHEA JACQUELINE,INFECTION AND IMMUNITY,米国,1999年 1月 1日,V67 N1,P213-219
MEDINA E,INFECTION AND IMMUNITY US AMERICAN SOCIETY FOR MICROBIOLOGY,米国,1999年 3月 1日,V67 N3,P1093-1099
CHATFIELD,VACCINE,英国,1992年,V10 N1,P53-60
LEVINE MYRON M,JOURNAL OF BIOTECHNOLOGY,1996年,V44 N1-3,P193-196
DOUGAN G,ADVANCES IN VETERINARY SCIENCE AND COMPARATIVE MEDICINE US ACADEMIC PRESS,米国,1989年,V33,P271-300
HOHMANN E L,VACCINE,米国,1996年,V14 N1,P19-24
LOWE,INFECTION AND IMMUNITY US AMERICAN SOCIETY FOR MICROBIOLOGY,米国,1990年,V67 M2,P700-707
SCHOEDEL F,JOURNAL OF IMMUNOLOGY,1990年,V145 N12,P4317-4321
HENSEL MICHAEL,MOLECULAR MICROBIOLOGY,1997年,V24 N1,P155-167
MEDINA E,INFECTION AND IMMUNITY US AMERICAN SOCIETY FOR MICROBIOLOGY,米国,1999年 3月 1日,V67 N3,P1093-1099
CHATFIELD,VACCINE,英国,1992年,V10 N1,P53-60
LEVINE MYRON M,JOURNAL OF BIOTECHNOLOGY,1996年,V44 N1-3,P193-196
DOUGAN G,ADVANCES IN VETERINARY SCIENCE AND COMPARATIVE MEDICINE US ACADEMIC PRESS,米国,1989年,V33,P271-300
HOHMANN E L,VACCINE,米国,1996年,V14 N1,P19-24
LOWE,INFECTION AND IMMUNITY US AMERICAN SOCIETY FOR MICROBIOLOGY,米国,1990年,V67 M2,P700-707
SCHOEDEL F,JOURNAL OF IMMUNOLOGY,1990年,V145 N12,P4317-4321
HENSEL MICHAEL,MOLECULAR MICROBIOLOGY,1997年,V24 N1,P155-167
Attorney, Agent or Firm:
Shohei Oguri
Hironori Honda
Toshimitsu Ichikawa
Hironori Honda
Toshimitsu Ichikawa