Title:
5-HT6親和性を有するピペリジン-インドール化合物
Document Type and Number:
Japanese Patent JP4597386
Kind Code:
B2
Abstract:
Described herein are indole compounds with affinity for the 5-HT6 receptor, which have general formula (I) wherein, R<1> is selected from the group consisting of H and C1-4alkyl; R<2> is selected from the group consisting of H, C1-4alkyl and benzyl; ----- represents a single or double bond; R<3> is selected from the group consisting of COR<5> and SO2R<5>; R<4a> is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R<4b> is selected from the group consisting of H, hydroxy, halo, C3-7cycloalkyloxy, C1-4alkoxy, C1-4alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; R<4c> is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R<4d> is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; and R<5> is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C1-4alkoxy, C1-4alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C1-4alkylcarbonyl, C1-4alkoxycarbonyl and C1-4alkylS-. Also described is the use of the compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.
Inventors:
Slavie, Abdelmalik
Edwards, Lewis
O'Brien, Anne
Shin, Tao
Tahim, Ashok
Edwards, Lewis
O'Brien, Anne
Shin, Tao
Tahim, Ashok
Application Number:
JP2000612293A
Publication Date:
December 15, 2010
Filing Date:
April 21, 1999
Export Citation:
Assignee:
NPS Pharmaceuticals, Inc.
International Classes:
C07D401/04; A61K31/454; A61P21/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D409/14
Foreign References:
| WO1997047302A1 |
Attorney, Agent or Firm:
Okabe
Masao Okabe
Shinichi Usui
Norimichi Takanashi
Tsuneo Kobayashi
Masao Okabe
Shinichi Usui
Norimichi Takanashi
Tsuneo Kobayashi