Title:
優れた生物学的利用能を持つ塩基性薬剤組成物
Document Type and Number:
Japanese Patent JP4608046
Kind Code:
B2
Abstract:
A composition comprising a basic drug, a drug which forms a zwitterion, or a salt of either entity, admixed with a polymer selected from hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate trimellitate (CAT), cellulose acetate phthalate (CAP), hydroxypropylcellulose acetate phthalate (HPCAP), hydroxypropylmethyl-cellulose acetate phthalate (HPMCAP), and methylcellulose acetate phthalate (MCAP). The compositions having improved solubility, hence bioavailability, in the small intestine; Processes for testing such compositions, and methods of using such compositions. The compositions comprise the basic drug, zwitterion, or salt and one or more of the aforementioned polymers. The invention further relates to a method for increasing the bioavailability of a basic or a zwitterionic drug comprising co-administering the basic drug, the zwitterionic drug, or the salt, with one or more of the aforementioned polymers.
Inventors:
William John Curatoro
James Alan Shriver Nightingale
Ravi Mysore Shanker
Stephen Charles Sutton
James Alan Shriver Nightingale
Ravi Mysore Shanker
Stephen Charles Sutton
Application Number:
JP2000031715A
Publication Date:
January 05, 2011
Filing Date:
February 09, 2000
Export Citation:
Assignee:
BEND RESEARCH,INCORPORATED
International Classes:
A61K47/38; A61K9/00; A61K9/14; A61K9/16; A61K9/20; A61K9/48
Domestic Patent References:
| JP11116502A | ||||
| JP9020663A | ||||
| JP7330585A | ||||
| JP60087217A | ||||
| JP60087216A | ||||
| JP59128323A | ||||
| JP2292229A |
Foreign References:
| WO1996019200A1 | ||||
| WO1993000889A1 |
Other References:
Journal of Pharmaceutical Sciences Vol.82,No.7,p737~743(1993.July)
International Journal of Pharmaceutics,1992年9月,Vol.85,p141~147
International Journal of Pharmaceutics,1992年9月,Vol.85,p141~147
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya