Title:
タンパク質工学
Document Type and Number:
Japanese Patent JP4633930
Kind Code:
B2
Abstract:
A method of protein engineering is provided wherein a searchable computer database is created comprising entries in the form of descriptions of a location and orientation in 3D space of side chains of the constituent amino acid residues of a framework protein. A query is created which corresponds to a description of a location and orientation in 3D space of respective side chains of amino acid residues of a sample protein. The location and orientation in 3D space of constituent side-chains is preferably described as a Calpha Cbeta vector. The query is used to search the database and thereby identify a hit which corresponds to a framework protein having structural similarity with said sample protein. Framework protein "hits" so identified may be suitable candidates for further modification. A particular advantage of the present invention is that a modified framework protein may display one or more desired characteristics, such as a function similar to or inhibitory of the sample protein.
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Inventors:
Smythe, Mark Leslie
Dolly, Michael John
Andrews, Peter Ronald
Dolly, Michael John
Andrews, Peter Ronald
Application Number:
JP2000577199A
Publication Date:
February 16, 2011
Filing Date:
October 21, 1999
Export Citation:
Assignee:
THE UNIVERSITY OF QUEENSLAND
International Classes:
G01N33/50; G16B50/30; C07K1/00; C07K14/535; C07K14/54; C07K14/61; G01N33/15; G01N33/68; G06F17/30; G16B15/20
Domestic Patent References:
| JP7028844A |
Other References:
Lauri, G.,CAVEAT: a program to facilitate the design of organic molecules,Journal of computer-aided molecular design,1994年 2月,Vol.8, No.1,p.51-66
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda