Title:
ペルオキシソーム増殖因子活性化受容体のリガンドとしてのN-アシル窒素ヘテロ環
Document Type and Number:
Japanese Patent JP4637843
Kind Code:
B2
Abstract:
Compounds of the formula provide pharmacological agents which bind to Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis, Crohn's disease, and conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X.
Inventors:
Gary Michael Xander
Sarassani Lara Raj Bedananda
Sarassani Lara Raj Bedananda
Application Number:
JP2006529884A
Publication Date:
February 23, 2011
Filing Date:
May 19, 2004
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D413/10; A61K31/422; A61K31/427; A61P5/50; A61P43/00; C07D207/16; C07D401/12; C07D403/12; C07D413/12; C07D417/12
Domestic Patent References:
| JP11209343A | ||||
| JP2002541138A | ||||
| JP2005511634A |
Foreign References:
| US5045540 | ||||
| WO2002096357A1 | ||||
| WO2002028433A1 |
Other References:
GANTE,J. et al.,Peptide synthesis, I. A new carboxamide synthesis,Chemiker-Zeitung,1985年,Vol.109, No.4,p.155-156
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Mitsutaka Iwasaki
Shoji Nakajima